Pyruvate prevents the ATP depletion caused by formaldehyde or calcium-chelator esters in the human red cell
García-Sancho, J
| HERO ID | 1578836 |
|---|---|
| In Press | No |
| Year | 1985 |
| Title | Pyruvate prevents the ATP depletion caused by formaldehyde or calcium-chelator esters in the human red cell |
| Authors | García-Sancho, J |
| Journal | Biochimica et Biophysica Acta |
| Volume | 813 |
| Issue | 1 |
| Page Numbers | 148-150 |
| Abstract | Formaldehyde released during hydrolysis of calcium-chelator esters incorporated into cells blocks glycolysis in the human erythrocyte (Tiffert, T., García-Sancho, J. and Lew, V.L. (1984) Biochim. Biophys. Acta 773, 143-156). This blockade is due to the inhibition of glyceraldehyde-3-phosphate dehydrogenase by NAD+ depletion caused by enzymatic oxidation of formaldehyde coupled to NADH production. The addition of pyruvate to the incubation medium prevents or reverts ATP depletion. |
| Doi | 10.1016/0005-2736(85)90357-8 |
| Pmid | 3970916 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |