Reproductive and developmental toxicity screening test in rats by oral gavage
| HERO ID | 1576870 |
|---|---|
| Year | 2004 |
| Title | Reproductive and developmental toxicity screening test in rats by oral gavage |
| Authoring Organization | Huntingdon Life Sciences |
| Publisher Text | Lyondell Chemical Company |
| City | East Millstone, NJ |
| Abstract | Groups of 12 male and 12 female rats received the test substance once daily by oral gavage at dose levels of 64, 160, 400, or 1000 mg/kg/day. F0 animals at 1000 mg/kg/day there was mild to moderate toxicity, including some transient lethargy, ataxia, and an initial reduction in male body weight gain. During late gestation, dams showed slight reduced weight gain. Pup body weight at birth was reduced by 10% progressing to a 15% deficiency by PND 7. During lactation the F0 dams showed reduced feed consumption. Increased F0 male kidney and liver weight at this dosage was suggestive of metabolic induction/accommodation, while a small (8%) increase in testis weight was considered to be of doubtful importance, particularly in the absence of any histological change. At 400 mg/kg/day there was a lower incidence of transient mild lethargy/ataxia in females only, beginning after approximately 2 weeks of treatment, but not seen after about the fourth week of treatment. At 160 and 64 mg/kg/day there was only a minor increase in F0 male kidney weight. was no definite effect of direct dosing of offspring for one week after weaning at the same dose levels as were received by their parents. AEL for this study was 160 mg/kg/day. |
| Report Number | Study No. 03-4254 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | HLS (2004). Study No. 03-4254. TBA: Reproduction/Developmental Toxicity Screening in Rats. Huntingdon Life Sciences, East Millstone, NJ. Report submitted to Propylene Carbonate/t-Butyl Alcohol Committee, Washington, DC, February 9. |
| Is Public | Yes |