Highly stereoselective, cobalt(III)-directed Mannich additions in water yielding α-methylamino acid products
Oerum, S; Krabbe, P; Schau-Magnussen, M; Furbo, S; Bendix, J; Hammershøi, A
| HERO ID | 1525969 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Highly stereoselective, cobalt(III)-directed Mannich additions in water yielding α-methylamino acid products |
| Authors | Oerum, S; Krabbe, P; Schau-Magnussen, M; Furbo, S; Bendix, J; Hammershøi, A |
| Journal | Dalton Transactions (Online) |
| Volume | 42 |
| Issue | 1 |
| Page Numbers | 292-298 |
| Abstract | Highly stereoselective and rapid (<1 min) addition reactions to the imine double bond of 2-(methylimino)acetate complexes [L(4)Co(O(2)CCH=NCH(3))](2+) [L(4) = (en)(2) (7), (tren) (11)] were achieved in aqueous solution with nitromethane, ethyl 3-oxobutanoate or diethyl malonate. The molecular structures of two product complexes, rac-(Δ*-R(C)*-S(N)*)-[Co(en)(2)(O(2)CCH[CH(2)NO(2)]NHCH(3))]ZnCl(4) and rac-(Δ*-R(C)*-S(N)*)-[Co(en)(2)(O(2)CCH[CH(2)COCH(3)]NHCH(3))]ZnCl(4), were established by X-ray diffraction. |
| Doi | 10.1039/c2dt32250a |
| Pmid | 23168834 |
| Wosid | WOS:000312218100032 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000312218100032 |
| Is Public | Yes |
| Language Text | English |