Mono- and digalactosyldiacylglycerols: potent nitric oxide inhibitors from the marine microalga Nannochloropsis granulata
Banskota, AH; Stefanova, R; Gallant, P; Mcginn, PJ
| HERO ID | 1524678 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Mono- and digalactosyldiacylglycerols: potent nitric oxide inhibitors from the marine microalga Nannochloropsis granulata |
| Authors | Banskota, AH; Stefanova, R; Gallant, P; Mcginn, PJ |
| Journal | Journal of Applied Phycology |
| Volume | 25 |
| Issue | 2 |
| Page Numbers | 349-357 |
| Abstract | Chemical investigation of a marine microalga, Nannochloropsis granulata, led to the isolation of four digalactosyldiacylglycerols namely, (2S)-1-O-eicosapentaenoyl-2-O-palmitoyl-3-O-(beta-d-galactopyranosyl-6-1 alpha-d- galactopyranosyl)-glycerol (1), (2S)-1-O-eicosapentaenoyl-2-O-palmitoleoyl-3-O-(beta-d- galactopyranosyl-6-1 alpha-d-galactopyranosyl)-glycerol (2), (2S)-1-O-eicosapentaenoyl-2-O- myristoyl-3-O-(beta-d-galactopyranosyl-6-1 alpha-d-galactopyranosyl)-glycerol (3), and (2S)-1,2- bis-O-eicosapentaenoyl-3-O-(beta-d-galactopyranosyl-6-1 alpha-d-galactopyranosyl)-glycerol (4), together with their monogalactosyl analogs (5-8). Among the isolated galactolipids 2 and 3 were new natural products. Complete stereochemistry of 1, 4, 5, 7, and 8 was determined for the first time by both spectroscopic techniques and classical degradation methods. Both mono- and digalactosyldiacylglycerols isolated from N. granulata possessed strong nitric oxide (NO) inhibitory activity against lipopolysaccharide-induced NO production in RAW264.7 macrophage cells through downregulation of inducible nitric oxide synthase expression indicating the possible use as anti-inflammatory agents. |
| Doi | 10.1007/s10811-012-9869-2 |
| Wosid | WOS:000316023400001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000316023400001 |
| Is Public | Yes |
| Keyword | Nannochloropsis granulata; Monogalactosyldiacylglycerol; Digalactosyldiacylglycerol; Nitric oxide; Inducible nitric oxide synthase |