Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma
Hussain, S; Laumbach, R; Coleman, J; Youssef, H; Kelly-Mcneil, K; Ohman-Strickland, P; Zhang, J; Kipen, H
HERO ID
1518982
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 1518982 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma |
| Authors | Hussain, S; Laumbach, R; Coleman, J; Youssef, H; Kelly-Mcneil, K; Ohman-Strickland, P; Zhang, J; Kipen, H |
| Journal | Journal of Occupational and Environmental Medicine |
| Volume | 54 |
| Issue | 10 |
| Page Numbers | 1186-1191 |
| Abstract | <strong>OBJECTIVE: </strong>To determine whether oxidative/nitrosative stress plays a role in the acute effects of diesel exhaust (DE) on subjects with asthma.<br /><br /><strong>METHODS: </strong>In this crossover study, 16 subjects with mild to moderate asthma were exposed to clean filtered air or diluted DE (300 μg/m as PM2.5) for 1 hour with intermittent exercise.<br /><br /><strong>RESULTS: </strong>Airway hyperreactivity increased 24 hours after exposure to DE compared with clean filtered air (PC20, 14.9 mg/mL vs 19.7 mg/mL; P = 0.012). Nitrite in exhaled breath condensate was elevated immediately after diesel exposure (P = 0.052) and remained elevated 4 and 24 hours after exposure.<br /><br /><strong>CONCLUSIONS: </strong>After exposure to DE, subjects with asthma demonstrated increased airway hyperreactivity and obstruction. Increased nitrite in exhaled breath condensate, in the absence of increased exhaled nitric oxide, suggests a noninflammatory oxidative stress mechanism by which DE affects the lung. |
| Doi | 10.1097/JOM.0b013e31826bb64c |
| Pmid | 23001278 |
| Wosid | WOS:000309794200005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000309794200005 |
| Is Public | Yes |
| Language Text | English |