Anatomic relationships of the human arcuate nucleus of the medulla: a DiI-labeling study
Zec, N; Filiano, JJ; Kinney, HC
HERO ID
1514965
Reference Type
Journal Article
Year
1997
Language
English
PMID
| HERO ID | 1514965 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Anatomic relationships of the human arcuate nucleus of the medulla: a DiI-labeling study |
| Authors | Zec, N; Filiano, JJ; Kinney, HC |
| Journal | Journal of Neuropathology and Experimental Neurology |
| Volume | 56 |
| Issue | 5 |
| Page Numbers | 509-522 |
| Abstract | The arcuate nucleus (ARC) at the ventral surface of the human medulla has been historically considered a precerebellar nucleus. More recently, it has been implicated in central chemoreception, cardiopulmonary coupling and blood pressure responses. A deficiency of the ARC has been reported in a subset of putative human developmental disorders of ventilatory function. To investigate anatomic relationships of the ARC with brainstem regions involved in cardiorespiratory control, we applied crystals of DiI, a lipophilic dye which labels cells and cell processes by lateral diffusion along cell membranes, to 23 paraformaldehyde-fixed human fetal brainstems at 19 to 22 weeks postconceptional age. After 7 to 15.5 months diffusion, serial frozen sections were examined by florescence microscopy. DiI diffusion from the ARC labeled fibers and cell bodies in the medullary raphé, and the external arcuate fibers. Diffusion from the medullary raphé [corrected] labeled the reticular formation, medullary raphé, and the ARC. Diffusion from the pyramid and the basis pontis (negative control) labeled the corticospinal tract, with no labeling of the medullary raphé or ARC. The results suggest the existence of cellular connections between the ARC and the caudal raphé, a region implicated in cardiorespiratory control. |
| Doi | 10.1097/00005072-199705000-00007 |
| Pmid | 9143264 |
| Wosid | WOS:A1997WY07300007 |
| Url | http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00005072-199705000-00007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | arcuate nucleus; brainstem; carbocyanines; cardiovascular control; chemoreceptors; neural pathways; Raphe nuclei |
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