Studies of AIDS vaccination using an ex vivo feline immunodeficiency virus model: protection conferred by a fixed-cell vaccine against cell-free and cell-associated challenge differs in duration and is not easily boosted
Matteucci, D; Pistello, M; Mazzetti, P; Giannecchini, S; Del Mauro, D; Lonetti, I; Zaccaro, L; Pollera, C; Specter, S; Bendinelli, M
HERO ID
1514943
Reference Type
Journal Article
Year
1997
Language
English
PMID
| HERO ID | 1514943 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Studies of AIDS vaccination using an ex vivo feline immunodeficiency virus model: protection conferred by a fixed-cell vaccine against cell-free and cell-associated challenge differs in duration and is not easily boosted |
| Authors | Matteucci, D; Pistello, M; Mazzetti, P; Giannecchini, S; Del Mauro, D; Lonetti, I; Zaccaro, L; Pollera, C; Specter, S; Bendinelli, M |
| Journal | Journal of Virology |
| Volume | 71 |
| Issue | 11 |
| Page Numbers | 8368-8376 |
| Abstract | Cats immunized with cells infected with a primary isolate of feline immunodeficiency virus (FIV) and fixed with paraformaldehyde were challenged with cell-free or cell-associated homologous virus obtained ex vivo. Complete protection was observed in animals challenged with cell-free virus 4 months after completion of vaccination (p.v.) or with cell-associated virus 12 months p.v. In contrast, no protection was observed in cats challenged with cell-free virus 12 or 28 months p.v. or with cell-associated virus 37.5 months p.v. Prior to the 28- and 37.5-month challenges, the animals had received a booster dose of vaccine that had elicited a robust anamnestic immune response. These results show that vaccine-induced protection against ex vivo FIV is achievable but is relatively short-lived and can be difficult to boost. |
| Doi | 10.1128/JVI.71.11.8368-8376.1997 |
| Pmid | 9343192 |
| Wosid | WOS:A1997YB14300036 |
| Url | https://JVI.asm.org/content/71/11/8368 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | AIDS Vaccines/ immunology; Animals; Antigens, Viral/immunology; Cell-Free System; Disease Models, Animal; Immunization, Secondary; Immunodeficiency Virus, Feline/ immunology; Immunologic Memory; RNA, Viral/analysis; Time Factors; Vaccination |