Prenatal Exposure to Organochlorine Compounds and Birth Size
Lopez-Espinosa, MJ; Murcia, M; Iniguez, C; Vizcaino, E; Llop, S; Vioque, J; Grimalt, JO; Rebagliato, M; Ballester, F
HERO ID
1510260
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 1510260 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Prenatal Exposure to Organochlorine Compounds and Birth Size |
| Authors | Lopez-Espinosa, MJ; Murcia, M; Iniguez, C; Vizcaino, E; Llop, S; Vioque, J; Grimalt, JO; Rebagliato, M; Ballester, F |
| Journal | Pediatrics |
| Volume | 128 |
| Issue | 1 |
| Page Numbers | E127-E134 |
| Abstract | <strong>OBJECTIVE: </strong>To investigate the possible association between birth size and cord concentrations of some organochlorine compounds (OCs), including 4,4'-dichlorodiphenyltrichloroethane (DDT), 4,4'-1,1-dichloro-2,2-bis(p-dichlorodiphenyl)ethylene (DDE), hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), 4 polychlorinated biphenyl (PCB) congeners (118, 138, 153, and 180), and their sum (ΣPCBs) in a birth cohort in Valencia, Spain.<br /><br /><strong>STUDY DESIGN: </strong>A total of 494 mothers and their newborns (born 2003-2006) participated in the study. Multivariate linear regression analyses were performed between birth weight, length, or head circumference and OC concentrations.<br /><br /><strong>RESULTS: </strong>Median concentrations of 4,4'-DDT, 4,4'-DDE, HCB, β-HCH, and ΣPCBs were 0.02, 0.46, 0.22, 0.09, and 0.35 ng/mL, respectively. For birth weight there was a significant decrease of 63 and 107 g for each 10-fold increase in cord serum 4,4'-DDT and 4,4'-DDE concentrations, and a marginally significant decrease of 79 and 53 g for each 10-fold increase in HCB and β-HCH concentrations. A significant decrease of 0.39 cm in birth length was found for each 10-fold increase in HCB concentrations. For newborns with cord 4,4'-DDT concentrations above the median there was a significant decrease of 0.26 cm in birth head circumference.<br /><br /><strong>CONCLUSIONS: </strong>These results reveal that prenatal exposure to some OCs could impair the anthropometric development of the fetus, reducing the birth weight, length, and head circumference. |
| Doi | 10.1542/peds.2010-1951 |
| Pmid | 21669889 |
| Wosid | WOS:000292299500017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000292299500017 |
| Is Public | Yes |
| Language Text | English |
| Keyword | birth weight; length; head circumference; DDT; DDE; HCB; HCH; PCB |