Biochemical blood parameters in pregnant mink fed PCB and fractions of PCB
Edqvist LE; Madej, A; Forsberg, M
HERO ID
1486360
Reference Type
Journal Article
Year
1992
Language
English
| HERO ID | 1486360 |
|---|---|
| In Press | No |
| Year | 1992 |
| Title | Biochemical blood parameters in pregnant mink fed PCB and fractions of PCB |
| Authors | Edqvist LE; Madej, A; Forsberg, M |
| Journal | Ambio |
| Volume | 21 |
| Issue | 8 |
| Page Numbers | 577-581 |
| Abstract | Biochemical parameters in blood and urine of pregnant mink fed commercial PCB, CB fractions and mixtures of the latter were examined. Mink were fed PCB fractions starting about 35 days before mating and continuing for 50 days thereafter. In 1990, mink were exposed to PCB for 53-69 days and were sacrificed 10, 17 and 26 days after mating. Blood samples were obtained at the time of sacrifice. No significant alterations were registered for the urinary parameters. Animals fed commercial PCB, but not fractions of CBs, all had elevated alanine aminotransferase (S-ALAT) (p < 0.05). Mink fed commercial PCB, individual or combined CB fractions had lowered (p < 0.05) alkaline phosphatase (S-ALP). Lowered (p < 0.05) serum bile acids (S-BA) were recorded in animals fed commercial PCB or 2-4-ortho + 1 -ortho + 0-ortho and 2-4-ortho + 0-ortho. The presence of bi- and tricyclic contaminants counteracted some of the observed biochemical changes, in particular decreases in S-fructosamine and in S-cholesterol. This protective effect and the lack of reponse in animals fed the contaminants could be attributed to induction of catalytic enzymes. Patterns of S-ALAT, S-ALP, S-BA, S-cholesterol and S-fructosamine for animals fed 2-4-ortho resembled the pattern for the control groups, whereas the combination of 2-4-ortho + 0-ortho CBs resulted in a pattern which was similar to that in animals fed commercial PCB. Significant differences from control animals were more frequent in animals given 0-ortho than 1 -ortho CBs. The patterns of biochemical changes for groups of animals fed 0-ortho CBs alone or in combination with other CBs best reproduced the pattern of the animals fed commercial PCB. The biochemical changes observed indicate the feeding of PCB or fractions of CBs causes a disturbance in hepatocytes |
| Wosid | WOS:A1992KF89100017 |
| Url | http://www.jstor.org/stable/4314018 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-212048</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Polychlorinated biphenyls</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>In vivo studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Laboratory animals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Feeding study</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical indicators</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Liver function</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Chemical composition</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Chemical structure</kw> |
| Relationship(s) |
|