Urinary excretion of cortisol and oestrone sulfate in pregnant mink fed PCB and fractions of PCB
Madej, A; Forsberg, M; Edqvist L-E
HERO ID
1482582
Reference Type
Journal Article
Year
1992
Language
English
| HERO ID | 1482582 |
|---|---|
| In Press | No |
| Year | 1992 |
| Title | Urinary excretion of cortisol and oestrone sulfate in pregnant mink fed PCB and fractions of PCB |
| Authors | Madej, A; Forsberg, M; Edqvist L-E |
| Journal | Ambio |
| Volume | 21 |
| Issue | 8 |
| Page Numbers | 582-585 |
| Abstract | The effects of technical polychlorinated biphenyl (PCB) preparations on urinary excretion of cortisol and estrone-sulfate in pregnant minks were investigated. Female minks (Mustela-vison) were administered diets containing: 2 milligrams (mg) Clophen-A50 (8068448); clophen fractions consisting of PCBs containing one to four chlorine atoms substituted in the ortho position (noncoplanar PCBs) or nonortho substituted PCBs (planar PCBs); a synthetic mixture of planar PCBs; or a mixture of polychlorinated naphthalenes and dibenzofuran contaminants (contaminant fraction) for 84 to 96 days (experiment-I). Other minks were fed diets containing 1.64mg aroclor-1254 (11097691) and the analogous fractions used in experiment-I for 79 to 94 days (experiment-II). Animals in both experiments were mated 4 to 6 weeks after the start of dosing. Dosing was continued up to 5 days postpartum. In experiment-I, all groups excreted similar amounts of cortisol for 10 to 15 days after mating. In clophen fed minks, significantly elevated amounts of cortisol were excreted about 30 days before delivery. Cortisol excretion in minks fed the contaminant fraction was also increased 25 and 30 days before delivery. Estrone-sulfate excretion was significantly increased only in clophen fed animals 10 days before to 5 days after delivery. In experiment-II, aroclor-1254 fed minks excreted significantly larger amounts of cortisol than the other groups 33 to 29 days before delivery. Excretion of cortisol by mink fed fractions containing planar and noncoplanar PCBs was significantly increased 32 and 21 to 25 days before delivery. All groups showed increased excretion of estrone-sulfate between 42 and 17 days before delivery. The increases were progressive and similar in all groups. The authors conclude that PCB feeding during certain stages of pregnancy increases urinary excretion of cortisol and estrone-sulfate in minks. When comparing with previous fetal resorption data, the study data indicate that the ovary or corpus luteum may be the source of urinary estrone-sulfate. |
| Wosid | WOS:A1992KF89100018 |
| Url | http://www.jstor.org/stable/4314019 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-212049</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>In vivo studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Laboratory animals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Polychlorinated biphenyls</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Feeding study</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Urinalysis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Chemical composition</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Hormone activity</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Estrogenic hormones</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Sexual reproduction</kw> |
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