Chronic toxicity of nitrogen dioxide: II. Effect on histopathology of lung tissue
Blair, WH; Henry, MC; Ehrlich, R
HERO ID
14815
Reference Type
Journal Article
Year
1969
Language
English
PMID
| HERO ID | 14815 |
|---|---|
| In Press | No |
| Year | 1969 |
| Title | Chronic toxicity of nitrogen dioxide: II. Effect on histopathology of lung tissue |
| Authors | Blair, WH; Henry, MC; Ehrlich, R |
| Journal | Archives of Environmental Health |
| Volume | 18 |
| Issue | 2 |
| Page Numbers | 186-192 |
| Abstract | Mice were exposed to 0.5 ppm nitrogen dioxide (NO2) for 6, 18, and 24 hours daily. The lung alveoli were expanded in all mice exposed to NO2 from three to 12 months, with the highest degree of involvement at 12 months; thus the number of expanded alveoli appeared to increase with exposure time. The general impression was of early bronchiolar inflammation with reduction of distal airway size and a concomitant expansion of alveoli. The overall lesions appeared to be consistent with the development of early focal emphysema. Examination of the heart, liver, kidney, and spleen did not reveal any unique pathology. Mice exposed to NO2 and challenged with Klebsiella pneumoniae exhibited a marked reduction in functional lung tissue. |
| Doi | 10.1080/00039896.1969.10665391 |
| Pmid | 5764942 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Arch. Environ. Health 18: 186-192. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |