Acute hypertensive response to saline induced by vanadate, an insulinomimetic agent
Bursztyn, M; Mekler, J
HERO ID
1466095
Reference Type
Journal Article
Year
1993
Language
English
PMID
| HERO ID | 1466095 |
|---|---|
| In Press | No |
| Year | 1993 |
| Title | Acute hypertensive response to saline induced by vanadate, an insulinomimetic agent |
| Authors | Bursztyn, M; Mekler, J |
| Journal | Journal of Hypertension |
| Volume | 11 |
| Issue | 6 |
| Page Numbers | 605-609 |
| Abstract | OBJECTIVE: To investigate whether the reported insulin-like properties of vanadate may have hypertensinogenic actions in Sabra rats. DESIGN: Comparison of [3H]-deoxyglucose muscle uptake as well as blood pressure and its response to acute volume expansion and pressors infusions in 16 vanadate-treated (VT) and 12 control rats. METHODS: Rats drank either tap water or 0.2 g/l vanadate for 4 weeks. A trace amount of [3H]-deoxyglucose was administered intravenously to evaluate its plasma half-life and tissue uptake. Intra-arterial blood pressure was recorded in response to acute intravenous saline (4 ml/100 g body weight) and to incremental bolus injections of noradrenaline and angiotensin II (Ang II). RESULTS: Skeletal muscle uptake of [3H]-deoxyglucose was significantly higher in VT than in control rats. There was no difference between the blood pressure of VT or control rats; however, 2 h after saline loading the mean intra-arterial blood pressure was significantly higher in VT than in control rats. The Ang II-induced blood pressure rise was also significantly higher in VT rats. CONCLUSION: The insulin-like activity of vanadate may be associated with salt-sensitive hypertension. |
| Pmid | 8397239 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |