Dependence of the hypertensive effect of chronic vanadate administration on renal excretory function in the rat
Susić, D; Kentera, D
HERO ID
1466086
Reference Type
Journal Article
Year
1988
Language
English
PMID
| HERO ID | 1466086 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Dependence of the hypertensive effect of chronic vanadate administration on renal excretory function in the rat |
| Authors | Susić, D; Kentera, D |
| Journal | Journal of Hypertension |
| Volume | 6 |
| Issue | 3 |
| Page Numbers | 199-204 |
| Abstract | The effect of vanadate, an agent that in rats exerts potent vasoconstrictor and diuretic action on blood pressure, cardiac output, total peripheral resistance and plasma and extracellular fluid volume, was investigated in normal rats and in rats with diminished renal excretory function. In normal rats, chronic dietary vanadate did not affect blood pressure, but induced an increase in total peripheral resistance and a decrease in cardiac output, plasma and extracellular fluid volume. In rats with diminished renal excretory function, vanadate increased blood pressure and total peripheral resistance without affecting cardiac output, plasma and extracellular fluid volume. The results indicate that this agent, with predominant vasoconstrictor action, does not cause sustained hypertension unless renal excretory function is diminished. |
| Pmid | 3361118 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |