Cardiovascular system and kidney as specific targets of chronic exposure to vanadate in the rat: Functional and morphological findings
Carmignani, M; Boscolo, P; Volpe, AR; Togna, G; Masciocco, L; Preziosi, P
HERO ID
1466080
Reference Type
Book/Book Chapter
Year
1991
Language
English
PMID
| HERO ID | 1466080 |
|---|---|
| Year | 1991 |
| Title | Cardiovascular system and kidney as specific targets of chronic exposure to vanadate in the rat: Functional and morphological findings |
| Book Title | Recent Developments in Toxicology: Trends, Methods and Problems |
| Authors | Carmignani, M; Boscolo, P; Volpe, AR; Togna, G; Masciocco, L; Preziosi, P |
| Editor | Chambers, PL; Chambers, CM; Wiezorek, WD; Golbs, S |
| Publisher Text | Springer |
| City | Heidelberg, Germany |
| Volume | 14 |
| Page Numbers | 124-127 |
| Abstract | The physiological significance of vanadium (Va) and its mechanisms of cardiovascular (CV) and renal toxicity (following chronic exposure) remain contradictory (Nechay 1984). Pentavalent vanadate (Va+5, as analogue of phosphate) and tetravalent vanadyl (resembling the size of Mg+2) have many potential sites of action. However, it is yet to be established whether CV and renal effects of Va involve inhibition and/or stimulation of various enzymatic activities (for instance, Na+, K+, ATPase and adenylate cyclase, respectively) and are influenced by other ions (like Na+, K+, Mg+2 and Mn+2) and/or by the redox and metabolic states of the involved cells. Contradictory results also concern the possibility that Va is implicated in certain types of arterial hypertension (Carmignani et al 1990). |
| Doi | 10.1007/978-3-642-74936-0_24 |
| Pmid | 1805718 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Leipzig, Germany |
| Series | Archives of Toxicology |
| Isbn | 9783642749360 |
| Conference Name | European Societies of Toxicology Meeting |
| Conference Date | September 12–14, 1990 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Instrumental Neutron Activation Analysis Chronic Exposure Proximal Tubule Cell Cardiac Inotropism Pentavalent Vanadate |