The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain
Kim, HJu; Leeds, P; Chuang, DeMaw
HERO ID
1460623
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 1460623 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain |
| Authors | Kim, HJu; Leeds, P; Chuang, DeMaw |
| Journal | Journal of Neurochemistry |
| Volume | 110 |
| Issue | 4 |
| Page Numbers | 1226-1240 |
| Abstract | In the healthy adult brain, neurogenesis normally occurs in the subventricular zone (SVZ) and hippocampal dentate gyrus (DG). Cerebral ischemia enhances neurogenesis in neurogenic and non-neurogenic regions of the ischemic brain of adult rodents. This study demonstrated that post-insult treatment with a histone deacetylase inhibitor, sodium butyrate (SB), stimulated the incorporation of bromo-2'-deoxyuridine (BrdU) in the SVZ, DG, striatum, and frontal cortex in the ischemic brain of rats subjected to permanent cerebral ischemia. SB treatment also increased the number of cells expressing polysialic acid-neural cell adhesion molecule, nestin, glial fibrillary acidic protein, phospho-cAMP response element-binding protein (CREB), and brain-derived neurotrophic factor (BDNF) in various brain regions after cerebral ischemia. Furthermore, extensive co-localization of BrdU and polysialic acid-neural cell adhesion molecule was observed in multiple regions after ischemia, and SB treatment up-regulated protein levels of BDNF, phospho-CREB, and glial fibrillary acidic protein. Intraventricular injection of K252a, a tyrosine kinase B receptor antagonist, markedly reduced SB-induced cell proliferation detected by BrdU and Ki67 in the ipsilateral SVZ, DG, and other brain regions, blocked SB-induced nestin expression and CREB activation, and attenuated the long-lasting behavioral benefits of SB. Together, these results suggest that histone deacetylase inhibitor-induced cell proliferation, migration and differentiation require BDNF-tyrosine kinase B signaling and may contribute to long-term beneficial effects of SB after ischemic injury. |
| Doi | 10.1111/j.1471-4159.2009.06212.x |
| Pmid | 19549282 |
| Wosid | WOS:000268221500009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000268221500009 |
| Is Public | Yes |
| Language Text | English |
| Keyword | brain-derived neurotrophic factor; bromo-2'-deoxyuridine; cerebral ischemia; histone deacetylase inhibitors; K252a; neurogenesis |