The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties
Blank-Porat, D; Gruss-Fischer, Tal; Tarasenko, N; Malik, Zvi; Nudelman, A; Rephaeli, Ada
HERO ID
1458564
Reference Type
Journal Article
Year
2007
Language
English
PMID
| HERO ID | 1458564 |
|---|---|
| In Press | No |
| Year | 2007 |
| Title | The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties |
| Authors | Blank-Porat, D; Gruss-Fischer, Tal; Tarasenko, N; Malik, Zvi; Nudelman, A; Rephaeli, Ada |
| Journal | Cancer Letters |
| Volume | 256 |
| Issue | 1 |
| Page Numbers | 39-48 |
| Abstract | The antiangiogenic and antineoplastic activities of the butyric acid prodrugs AN-7 and AN-9 were demonstrated in vitro with HUVEC by inhibition of proliferation and vascular tubes formation, enhanced apoptosis, and inhibition of 22Rv-1 cells migration. In the sc implanted human prostate tumors (22Rv-1) in nude mice, AN-7 significantly inhibited Ki-67, HIF-1alpha, HER-2/neu, bFGF and increased PTEN level. AN-7 and AN-9 reduced hemoglobin accumulation in matrigel plugs implanted sc in Balb-c mice. Herein, we show that the anticancer activity of AN-7 and AN-9 can be attributed in part to their antiangiogenic activities suggesting potential therapeutic benefits for prostate cancer patients. |
| Doi | 10.1016/j.canlet.2007.05.011 |
| Pmid | 17611019 |
| Wosid | WOS:000250028000005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000250028000005 |
| Is Public | Yes |
| Language Text | English |
| Keyword | butyric acid prodrugs; prostate carcinoma; angiogenesis |