Dietary sodium gluconate protects rats from large bowel cancer by stimulating butyrate production
Kameue, C; Tsukahara, T; Yamada, K; Koyama, H; Iwasaki, Y; Nakayama, K; Ushida, K
HERO ID
1457148
Reference Type
Journal Article
Year
2004
Language
English
PMID
| HERO ID | 1457148 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | Dietary sodium gluconate protects rats from large bowel cancer by stimulating butyrate production |
| Authors | Kameue, C; Tsukahara, T; Yamada, K; Koyama, H; Iwasaki, Y; Nakayama, K; Ushida, K |
| Journal | Journal of Nutrition |
| Volume | 134 |
| Issue | 4 |
| Page Numbers | 940-944 |
| Abstract | Butyrate has an antitumorigenic effect on colorectal cancer cell lines. Dietary sodium gluconate (GNA) promotes butyrate production in the large intestine. Accordingly, we examined the effect of dietary GNA on tumorigenesis in the large intestine in rats. Male Fisher-344 rats (n = 32) were divided into 4 groups: 2 diets (with or without 50 g GNA/kg basal diet) X 2 treatments (with or without carcinogen administration). Colonic tumors were induced by 3 intraperitoneal injections of azoxymethane (115 mg/kg body wt, 1 time/wk) and dietary deoxycholic acid (2 g/kg basal diet). The experiment was conducted for 33 wk except for a few rats. Ingestion of GNA increased cecal butyrate concentration at the end of experiment (P < 0.01). No tumor development occurred in the untreated groups. Ingestion of GNA decreased the incidence of tumors in rats administered the carcinogen (37.5 vs. 100%, P < 0.05). Ingestion of GNA also decreased the mean number of tumors per rat (0.5 +/- 0.8 vs. 2.8 +/- 1.5, P < 0.01). beta-Catenin accumulation and TdT-mediated dUTP nick end labeling (TUNEL) positive cells in tumors were histochemically examined. The results of this study suggested that the antitumorigenic effect of GNA may involve the stimulation of apoptosis through enhanced butyrate production in the large intestine. |
| Doi | 10.1093/jn/134.4.940 |
| Pmid | 15051851 |
| Wosid | WOS:000220681700038 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | sodium gluconate; butyrate; colorectal cancer prevention; apoptosis; rat |
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