Catalytic Bioscavengers Human Butyrylcholinesterase and Paraoxonase Sequestered to the Center for CNS
Boado, RJ
| HERO ID | 1455504 |
|---|---|
| Year | 2009 |
| Title | Catalytic Bioscavengers Human Butyrylcholinesterase and Paraoxonase Sequestered to the Center for CNS |
| Authors | Boado, RJ |
| Volume | GRA and I |
| Abstract | The purpose of this research is to genetically engineer, express, and validate 2 novel biopharmaceutical fusion proteins, designated AGT-185 and AGT-186. Both proteins are fusion proteins of human paraoxonase (PON)-1 variants and a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR). The 2 proteins are intended for development as new treatments of the brain in organophosphate chemical nerve gas attacks. |
| Report Number | NTIS/02440008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Govt Reports Announcements and Index ISSN: |
| Is Public | Yes |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Central nervous system</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Humans</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicity</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Enzymes</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Proteins</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Butyrates</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cholinesterase</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Organophosphates</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Blood brain barrier</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Brain</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Monoclonal antibodies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Pon(Paraoxonase)</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Hir(Human insulin receptor)</kw> |