Testicular histopathology in deer mice (Peromyscus maniculatus) following exposure to polychlorinated biphenyl
Alston, DA; Tandler, B; Gentles, B; Smith, EE
HERO ID
1418042
Reference Type
Journal Article
Year
2003
Language
English
PMID
| HERO ID | 1418042 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | Testicular histopathology in deer mice (Peromyscus maniculatus) following exposure to polychlorinated biphenyl |
| Authors | Alston, DA; Tandler, B; Gentles, B; Smith, EE |
| Journal | Chemosphere |
| Volume | 52 |
| Issue | 1 |
| Page Numbers | 283-285 |
| Abstract | Adult deer mice testes were subjected to routine histopathology following exposure to Aroclor 1254 supplemented diet (5 ppm), for 30 days. Body and testicular weight revealed no statistical significance between the control and treated animals. From a histological standpoint the testes of the controls were similar to normal murids and other animals. In contrast, the testes from treated animals displayed seminiferous tubules with significant degenerative alterations. These alterations included fewer layers of seminiferous epithelium exaggerated intercellular spaces and appearance of pyknotic nuclei. Most tubules displayed subluminal nuclei that morphologically could be identified as part of spermatozoa heads and these usually lacked tails, indicating that the treatment interfered with spermiogenesis. Therefore, we concluded that Aroclor 1254 as an environmental contaminant is highly destructive to seminiferous tubules, and that these histological alterations undoubtedly are responsible for the depressed fertility in Peromyscus following chronic exposure to PCBs, that has been reported in the literature. |
| Doi | 10.1016/S0045-6535(03)00034-1 |
| Pmid | 12729713 |
| Wosid | WOS:000182897100031 |
| Url | https://linkinghub.elsevier.com/retrieve/pii/S0045653503000341 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | deer mice; Aroclor 1254; testes; reproduction |