Thyroid, bradycardic and hypothermic effects of perfluoro-n-decanoic acid in rats
Langley, AE; Pilcher, GD
HERO ID
1407873
Reference Type
Journal Article
Year
1985
Language
English
PMID
| HERO ID | 1407873 |
|---|---|
| In Press | No |
| Year | 1985 |
| Title | Thyroid, bradycardic and hypothermic effects of perfluoro-n-decanoic acid in rats |
| Authors | Langley, AE; Pilcher, GD |
| Journal | Journal of Toxicology and Environmental Health |
| Volume | 15 |
| Issue | 3-4 |
| Page Numbers | 485-491 |
| Abstract | A single ip injection of perfluoro-n-decanoic acid (PFDA) to male Wistar rats resulted in an initially rapid, then gradual decrease in food consumption and a parallel loss of body weight. Body temperatures and resting heart rates were significantly depressed by PFDA treatment. As early as 12 h following a single dose of PFDA, serum thyroxine (T4) levels were significantly reduced and remained depressed throughout the 8 day study. Serum triiodothyronine (T3) was reduced by 35% 12 h following PFDA treatment and remained at that level throughout the study. These preliminary data suggest that an action on the thyroid axis may be an early primary response to PFDA and that some of the observed subsequent effects may in part be secondary to the change in thyroid hormone levels. |
| Doi | 10.1080/15287398509530675 |
| Pmid | 4032495 |
| Wosid | WOS:A1985AQJ7200012 |
| Url | https://search.proquest.com/docview/14211530?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | effects on; perfluoro-n-decanoic acid; 3,5,3'-triiodothyronine; body temperature; heart rate; thyroid hormones; Toxicology Abstracts; X 24152:Chronic exposure |