Adenofibrosis in the rat liver, with persistence of polychlorinated biphenyls in adipose tissue
Kimbrough, RD; Linder, RE; Burse, VW; Jennings, RW
HERO ID
1404636
Reference Type
Journal Article
Year
1973
Language
English
PMID
| HERO ID | 1404636 |
|---|---|
| In Press | No |
| Year | 1973 |
| Title | Adenofibrosis in the rat liver, with persistence of polychlorinated biphenyls in adipose tissue |
| Authors | Kimbrough, RD; Linder, RE; Burse, VW; Jennings, RW |
| Journal | Archives of Environmental Health |
| Volume | 27 |
| Issue | 6 |
| Page Numbers | 390-395 |
| Abstract | The persistence of morphological changes in the liver produced by polychlorinated biphenyls (PCBs) was investigated. Male Sherman-rats were fed 500 parts per million (ppm) Aroclor-1254 (11097691) for 6 months. Five rats were killed 0, 1, 2, 3, 4, 6, 7, and 10 months after Aroclor feeding was discontinued. At autopsy, liver tissue was examined under electron and light microscopes. Adipose and liver tissue from exposed rats killed at 10 months and from unexposed controls were analyzed for PCBs by electron capture gas chromatography; adipose and hepatic composites were analyzed by gas chromatography/mass spectrometry. Livers of rats killed immediately comprised 6.32 percent of body weight, 3.6 percent at 4 months, and 3.34 percent at 8 months. Livers of control animals were 2.44 to 2.59 percent of body weight. Of 40 livers examined, hepatocytes were enlarged in 39, and all 40 showed either vacuolated or foamy cytoplasm because of increased lipid accumulation. Adenofibrosis was present in 36 livers, and a brown pigment was noted in the Kupffer cells and other macrophages in 25 livers. No signs of fibrosis regression were noted. Electron microscopy revealed numerous small lipid vacuoles in the cytoplasm of many hepatocytes, particularly in the latter part of the recovery phase. In adipose tissue, concentrations of PCBs ranged from 924 to 1688ppm. Liver concentrations ranged from 17.30 to 26.24ppm. The gas chromatogram was significantly different from that of standard Aroclor-1254. Three major Aroclor components were seen. These components contained isotopic clusters believed to be chlorines. The authors conclude that Aroclor consumption produces liver adenofibrosis. The reversibility of the lesion is not known. Metabolism of lower chlorinated biphenyls may account for the difference between Aroclors found in tissues and standard Aroclor-1254. |
| Doi | 10.1080/00039896.1973.10666410 |
| Pmid | 4356600 |
| Wosid | WOS:A1973R418900010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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