Early childhood lower respiratory illness and air pollution
Hertz-Picciotto, I; Baker, RJ; Yap, PS; Dostal, M; Joad, JP; Lipsett, M; Greenfield, T; Herr, CE; Benes, I; Shumway, RH; Pinkerton, KE; Sram, R
HERO ID
135917
Reference Type
Journal Article
Year
2007
Language
English
PMID
| HERO ID | 135917 |
|---|---|
| In Press | No |
| Year | 2007 |
| Title | Early childhood lower respiratory illness and air pollution |
| Authors | Hertz-Picciotto, I; Baker, RJ; Yap, PS; Dostal, M; Joad, JP; Lipsett, M; Greenfield, T; Herr, CE; Benes, I; Shumway, RH; Pinkerton, KE; Sram, R |
| Journal | Environmental Health Perspectives |
| Volume | 115 |
| Issue | 10 |
| Page Numbers | 1510-1518 |
| Abstract | BACKGROUND: Few studies of air pollutants address morbidity in preschool children. In this study we evaluated bronchitis in children from two Czech districts: Teplice, with high ambient air pollution, and Prachatice, characterized by lower exposures. OBJECTIVES: Our goal was to examine rates of lower respiratory illnesses in preschool children in relation to ambient particles and hydrocarbons. METHODS: Air monitoring for particulate matter < 2.5 microm in diameter (PM(2.5)) and polycyclic aromatic hydrocarbons (PAHs) was conducted daily, every third day, or every sixth day. Children born May 1994 through December 1998 were followed to 3 or 4.5 years of age to ascertain illness diagnoses. Mothers completed questionnaires at birth and at follow-up regarding demographic, lifestyle, reproductive, and home environmental factors. Longitudinal multivariate repeated-measures analysis was used to quantify rate ratios for bronchitis and for total lower respiratory illnesses in 1,133 children. RESULTS: After adjustment for season, temperature, and other covariates, bronchitis rates increased with rising pollutant concentrations. Below 2 years of age, increments in 30-day averages of 100 ng/m(3) PAHs and of 25 microg/m(3) PM(2.5) resulted in rate ratios (RRs) for bronchitis of 1.29 [95 % confidence interval (CI), 1.07-1.54] and 1.30 (95% CI, 1.08-1.58), respectively; from 2 to 4.5 years of age, these RRs were 1.56 (95% CI, 1.22-2.00) and 1.23 (95% CI, 0.94-1.62), respectively. CONCLUSION: Ambient PAHs and fine particles were associated with early-life susceptibility to bronchitis. Associations were stronger for longer pollutant-averaging periods and, among children > 2 years of age, for PAHs compared with fine particles. Preschool-age children may be particularly vulnerable to air pollution-induced illnesses. |
| Doi | 10.1289/ehp.9617 |
| Pmid | 17938744 |
| Wosid | WOS:000249904900046 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000249904900046 |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution; bronchitis; children's health; infant; particulate matter; PM(2.5); PAHs; polycyclic aromatic hydrocarbons; respiratory illness; volatile organic compounds |
| Is Qa | No |