Synthesis and characterization ol the new ambidentate O-cholesteryl-O-phenyl phosphorothioate ligand and its organoarsenic derivatives of phenoxarsin-10-yl and phenothiarsin-10-yl phosphorothioate
Lopez-Cardoso, M; Garcia, PGY; Garcia-Montalvo, V; Cea-Olivares, R
| HERO ID | 1349586 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Synthesis and characterization ol the new ambidentate O-cholesteryl-O-phenyl phosphorothioate ligand and its organoarsenic derivatives of phenoxarsin-10-yl and phenothiarsin-10-yl phosphorothioate |
| Authors | Lopez-Cardoso, M; Garcia, PGY; Garcia-Montalvo, V; Cea-Olivares, R |
| Journal | Heteroatom Chemistry |
| Volume | 11 |
| Issue | 1 |
| Page Numbers | 6-10 |
| Abstract | A new anionic phosphorothioate ligand that incorporates the bioactive cholesteryl group was obtained (2), Na(RR'P(S)O; R, O-phenyl; R', O-cholesteryl) from the phenylphosphoramidate (1) and NaH in dioxane. In order to test the coordination ability of 2, two organoarsenic derivatives were prepared O(C6H4)(2)AsS(O)PRR' (3) and S(C6H4)(2)AsS(O)PRR' (4) by reacting 2 with 10-chlorophenoxarsine or 10-chlorophenothiarsine. Compounds 2, 3, and 4 were characterized by elemental microanalysis, IR, multielement NMR (H-1, C-13, and P-31), and mass spectrometry. The spectroscopic data suggest that the ligand is bonded to the arsenic only through the sulfur donor atom in both organoarsenic derivatives. (C) 2000 John Wiley & Sons, Inc. |
| Doi | 10.1002/(SICI)1098-1071(2000)11:1<6::AID-HC2>3.0.CO;2-M |
| Wosid | WOS:000084808300002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000084808300002 |
| Is Public | Yes |