Sex dimorphic endocrine disruption following in utero exposure to di (2-ethylhexyl) phthalate
Pizzi, WJ; Mcfadden, HG
HERO ID
1334052
Reference Type
Journal Article
Subtype
Abstract
Year
2006
Language
English
| HERO ID | 1334052 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2006 |
| Title | Sex dimorphic endocrine disruption following in utero exposure to di (2-ethylhexyl) phthalate |
| Authors | Pizzi, WJ; Mcfadden, HG |
| Journal | Neurotoxicology and Teratology |
| Volume | 28 |
| Issue | 3 |
| Page Numbers | 420-421 |
| Abstract | Di (2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in polyvinyl chloride plastics. Routes of exposure for humans include inhalation, ingestion, and through medical fluids such as saline and blood. DEHP is a suspected endocrine disrupter and may have adverse effects following in utero exposure. In this report, we extend our previous findings showing multiple toxic effects following in utero exposure to DEHP which included testicular and reproductive deficits. The current study administered DEHP at a dose of 1000 mg/kg/bw from GD 8 and #150; 21. We assessed two measures of endocrine disruption following exposure to DEHP: anogenital distance (AGD) and nipple retention in neonatal males. DEHP reduced AGD in males (p<0.001), but had no significant effects in females. DEHP-exposed males showed increased nipple retention on PND 11 which occurred in 75% of pups (p<0.001). These results are most likely an outcome of DEHP acting as an antiandrogen. It should also be noted that since toxic effects in animal studies typically occur at high doses, the question of likely exposure levels in humans is often raised. Recently however, Swan et al. (2005, Env Hlth Perspectives, 113, 1056) reported a decrease in anogenital distance in male human infants related to their prenatal body burden of phthalates. |
| Wosid | WOS:000238519900036 |
| Url | http://www.sciencedirect.com/science/article/pii/S0892036206000493# |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Tucson, Arizona |
| Conference Name | Thirtieth Annual Meeting of the Neurobehavioral Teratology Society in conjunction with the Forty-Sixth Annual Meeting of the Teratology Society |
| Conference Date | June 24–28, 2006 |
| Comments | Source: Web of Science WOS:000238519900036 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Pregnancy; Animals; Sex Characteristics; Endocrine Disruptors/ TOXICITY; Prenatal Exposure Delayed Effects/CHEMICALLY INDUCED/PHYSIOPATHOLOGY; Urogenital Abnormalities/CHEMICALLY INDUCED/PHYSIOPATHOLOGY; Diethylhexyl Phthalate/ TOXICITY; Animals, Newborn |
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