Assessment of hepatoprotective role of Eucalyptus tereticornis leaf extract in Rattus norvegicus after vanadium intoxication
Saxena, PN; Shukla, A; Saxena, N; Arya, J
HERO ID
1324518
Reference Type
Journal Article
Year
2010
Language
English
| HERO ID | 1324518 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Assessment of hepatoprotective role of Eucalyptus tereticornis leaf extract in Rattus norvegicus after vanadium intoxication |
| Authors | Saxena, PN; Shukla, A; Saxena, N; Arya, J |
| Journal | National Academy Science Letters |
| Volume | 33 |
| Issue | 3-4 |
| Page Numbers | 95-101 |
| Abstract | The protective effect of Eucalyptus tereticornis leaf extract and its potency has been compared with Liv.52 following V(2)O(5) induced hepatotoxicity in albino rats. LD(50) estimated for V(2)O(5) was 69.6 mg/kg b.wt. The administered doses of V (2)O(5) were LD(50)/10(th) for acute and 1/7(th), 1/14(th) and 1/21(th) of sublethal close for subacute (7, 14 and 21 ds) respectively. Body weight, liver weight and hepatosomatic index were assessed. Hepatotoxicity was assessed in terms of hepatic total proteins, total lipids and total cholesterol. V,05 intoxication significantly increased liver weight, hepatosomatic index, total lipids and total cholesterol, while significantly decreased body weight and total proteins. Pretreatment with close of 100 mg/kg b.wt of Eucalyptus tereticornis leaf extract and 0.125 ml/kg b.wt. of Liv.52 syrup restored the increased liver weight, hepatosomatic index, total lipids and total cholesterol and decreased parameters like body weight and total proteins toward normalcy. The results reveal that Eucalyptus terelicornis leaf extract modulates V(2)O(5) toxicity like well known hepatoprotectant, however the modulation is less than Liv.52. |
| Wosid | WOS:000278206100008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000278206100008 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Vanadium pentaoxide (V(2)O(5)); Eucalyptus tereticornis; Liv.52; Liver biochemistry |