A contribution to the action of vanadium with particular reference to syphilis
Proescher, F; Seil, HA; Stillians, AW
HERO ID
1324261
Reference Type
Journal Article
Year
1917
Language
English
| HERO ID | 1324261 |
|---|---|
| In Press | No |
| Year | 1917 |
| Title | A contribution to the action of vanadium with particular reference to syphilis |
| Authors | Proescher, F; Seil, HA; Stillians, AW |
| Journal | American Journal of Syphilis |
| Volume | 1 |
| Page Numbers | 347-405 |
| Abstract | The toxicity of vanadium (Va) salts was determined in a variety of animals. The action of vanadium on the circulating blood cells was studied on rabbits. The distribution of Va in chronic and acute poisoning was determined. A careful macroscopic and microscopic examination was made of all animals poisoned by Va. Colloidal vanadium-pentoxide (1314621) and ammonium-metavanadate (7803556) were the most toxic salts while vanadyl-sulfate (27774136) and sodium-hexavanadate (12026083) were the least toxic compounds. Mice and rats were the most resistant to Va; rabbits and horses, the most sensitive. Va poisoning was dominated by two groups of symptoms which could develop simultaneously. One was the result of depression, and in severe intoxication, acute paralysis of the respiratory center. The other was due to pulmonary, kidney, and gastrointestinal lesions. The chief action of Va was exerted on the vascular system. In tolerated doses, Va had no influence on circulating blood. In chronic intoxication, the red cells were directly affected. The bone marrow sometimes showed an increase in the neutrophilic myelocytes, while the lymphoid elements were decreased. The authors conclude that the pathological changes characterize Va as a neurotoxic and a hemorrhagic endotheliotoxic poison with a hepatotoxic, nephrotoxic, and probably leukocytotoxic and hemotoxic component. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-119504</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Animal studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Pathogenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxic effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Respiratory system disorders</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Poisons</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Blood analysis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biological effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Physiological response</kw> |