Structure‐activity relationships for skin sensitisation potential of diacrylates and dimethacrylates
Roberts, DW
HERO ID
1322754
Reference Type
Journal Article
Year
1987
Language
English
PMID
| HERO ID | 1322754 |
|---|---|
| In Press | No |
| Year | 1987 |
| Title | Structure‐activity relationships for skin sensitisation potential of diacrylates and dimethacrylates |
| Authors | Roberts, DW |
| Journal | Contact Dermatitis |
| Volume | 17 |
| Issue | 5 |
| Page Numbers | 281-289 |
| Abstract | Apparently conflicting guinea pig sensitisation data on diacrylates and dimethacrylates published by 3 groups of authors, are analysed in terms of the RAJ model. This model, correlating sesitisation score with a combination of induction dose, chemical reactivity and lipophilicity, enables the major discrepancies to be rationalised. The data provide a striking example of the overload effect, in that some of the diacrylates have failed to show sensitisation when tested at high induction doses, but are revealed as strong sensitisers when tested by other authors at lower induction doses. |
| Doi | 10.1111/j.1600-0536.1987.tb01478.x |
| Pmid | 3436133 |
| Wosid | WOS:A1987L291000004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |