Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series
Geier, J; Lessmann, H; Becker, D; Bruze, M; Frosch, PJ; Fuchs, T; Jappe, U; Koch, P; Pföhler, C; Skudlik, C
HERO ID
1313686
Reference Type
Journal Article
Year
2006
Language
English
PMID
| HERO ID | 1313686 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series |
| Authors | Geier, J; Lessmann, H; Becker, D; Bruze, M; Frosch, PJ; Fuchs, T; Jappe, U; Koch, P; Pföhler, C; Skudlik, C |
| Journal | Contact Dermatitis |
| Volume | 55 |
| Issue | 6 |
| Page Numbers | 322-329 |
| Abstract | <strong>BACKGROUND: </strong>Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties.<br /><br /><strong>OBJECTIVES: </strong>To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF.<br /><br /><strong>PATIENTS/METHODS: </strong>Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients.<br /><br /><strong>RESULTS: </strong>7 patients reacted positively to the formaldehyde releaser 4,4'-methylenebis morpholine, and 6 of these patients also reacted to formaldehyde and/or other formaldehyde releasers. 4 patients reacted positively to myristyl alcohol tested at 10% petrolatum (pet.). Additionally, 20 doubtful or irritant reactions occurred. 1 patient each reacted positively to oleyl alcohol, MIPA, and AEPD. None of the other test substances mentioned above elicited any clear-cut positive reaction. Patch testing with well-known MWF allergens showed proportions of positive reactions, which were comparable to those from other studies, e.g. 11% to monoethanolamine, 8% to colophonium and 3%-5% to various preservatives.<br /><br /><strong>CONCLUSIONS: </strong>4,4'-methylenebis morpholine may be an important MWF allergen, although clinical relevance could not be stated definitely in every case. Myristyl alcohol should not be patch tested at 10% pet., but at a lesser concentration, due to irritant properties. |
| Doi | 10.1111/j.1600-0536.2006.00993.x |
| Pmid | 17101005 |
| Wosid | WOS:000242532300002 |
| Url | http://dx.doi.org/10.1111/j.1600-0536.2006.00993.x |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | 2-amino-2-ethyl-1,3-propanediol (AEPD); 1-amino-2-propanol (monoisopropanolamine; MIPA); contact allergy; formaldehyde; metalworking fluids; 4,4 '-methylenebis morpholine; myristyl alcohol; occupational; patch testing |
| Is Peer Review | Yes |
| Relationship(s) |
|