Reproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactation
Guerra, MT; Scarano, WR; de Toledo, FC; Franci, JAA; Kempinas, WDG
HERO ID
1312961
Reference Type
Journal Article
Year
2010
Language
English
PMID
| HERO ID | 1312961 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Reproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactation |
| Authors | Guerra, MT; Scarano, WR; de Toledo, FC; Franci, JAA; Kempinas, WDG |
| Journal | Reproductive Toxicology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 99-105 |
| Abstract | Phthalates are environmental contaminants used in the production of plastics, cosmetics and medical devices. Studies on the effects of phthalates on female reproductive health are particularly sparse and mostly restricted to high-dose exposure in rats. In the present study, pregnant rats were treated with 100mg/kg-d of di-eta-butyl-phthalate (DBP) or only the vehicle (control group), from GD 12 to GD 20 for evaluation of reproductive outcomes and fetal gonads analysis (F0), and from GD 12 to PND 21 to evaluate reproductive development and function on F1 female offspring. Results showed that all parameters were comparable between groups, although there was a significant increase in the fetal weight after DBP exposure. However, the body weight at birth was normal. Based on these data we can conclude that, in these experimental conditions, DBP did not disturb the reproductive development or function of female rats. |
| Doi | 10.1016/j.reprotox.2009.10.005 |
| Pmid | 19850123 |
| Wosid | WOS:000273802000013 |
| Url | https://search.proquest.com/docview/744716751?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000273802000013 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Maternal exposure; Di-eta-butyl-phthalate; Female offspring; Reproduction; Uterus; Ovary; Estrous cycle; Sexual behavior |