Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 mice
Fair, PA; Driscoll, E; Mollenhauer, MA; Bradshaw, SG; Yun, SH; Kannan, K; Bossart, GD; Keil, DE; Peden-Adams, MM
HERO ID
1276153
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 1276153 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 mice |
| Authors | Fair, PA; Driscoll, E; Mollenhauer, MA; Bradshaw, SG; Yun, SH; Kannan, K; Bossart, GD; Keil, DE; Peden-Adams, MM |
| Journal | Journal of Immunotoxicology |
| Volume | 8 |
| Issue | 1 |
| Page Numbers | 17-29 |
| Abstract | In the first part of a series of studies to account for perfluorooctane sulfonate (PFOS)-induced sheep red blood cell (SRBC)-specific immunoglobulin M (IgM) antibody suppression in mice, a survey of clinical and immunotoxicological endpoints was examined. Adult female B₆C₃F₁ mice were exposed orally for 28 days to a total administered dose (TAD) of 0, 0.1, 0.5, 1, or 5 mg PFOS/kg. Uterus wet weight was significantly decreased compared with control at the 5 mg/kg dose. No indications of wasting syndrome, malnutrition, alteration of thyroid homeostasis, or signs of overt toxicity were observed. Numbers of splenic CD19+/CD21⁻, CD19+/CD21+, B220+/CD40+, CD4+/CD154⁻, CD4+/CD154+, and MHC-II+ cells were not altered. Additionally, ex vivo interleukin-4 (IL-4), IL-5, and IL-6 production by in vitro anti-CD3- or phorbol myristate acetate-stimulated CD4+ T-cells was not affected. Ex vivo IL-6 production by B-cells was significantly increased by in vitro stimulation with either anti-CD40 or lipopolysaccharide. Increased IL-6 production by B-cells was the most sensitive endpoint assessed resulting in alterations at the lowest dose tested (0.1 mg/kg TAD) following anti-CD40 stimulation. Further studies are required to characterize effects on inflammatory markers such as IL-6 at environmentally relevant concentrations of PFOS and to determine the key events associated with PFOS-induced IgM suppression to address potential human health risks. |
| Doi | 10.3109/1547691X.2010.527868 |
| Pmid | 21261439 |
| Wosid | WOS:000287043100004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000287043100004 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Perfluorooctane sulfonate; PFOS; immune; cytokines; toxicity; CBC; hematology |
| Is Qa | No |