Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs)
Prince, MM; Ruder, AM; Hein, MJ; Waters, MA; Whelan, EA; Nilsen, N; Ward, EM; Schnorr, TM; Laber, PA; Davis-King, KE
HERO ID
116888
Reference Type
Journal Article
Year
2006
Language
English
PMID
| HERO ID | 116888 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs) |
| Authors | Prince, MM; Ruder, AM; Hein, MJ; Waters, MA; Whelan, EA; Nilsen, N; Ward, EM; Schnorr, TM; Laber, PA; Davis-King, KE |
| Journal | Environmental Health Perspectives |
| Volume | 114 |
| Issue | 10 |
| Page Numbers | 1508-1514 |
| Abstract | BACKGROUND: We expanded an existing cohort of workers (n = 2,588) considered highly exposed to polychlorinated biphenyls (PCBs) at two capacitor manufacturing plants to include all workers with at least 90 days of potential PCB exposure during 1939-1977 (n = 14,458). Causes of death of a priori interest included liver and rectal cancers, previously reported for the original cohort, and non-Hodgkin lymphoma (NHL), melanoma, and breast, brain, intestine, stomach, and prostate cancers, based on other studies. METHODS: We ascertained vital status of the workers through 1998, and cumulative PCB exposure was estimated using a new job exposure matrix. Analyses employed standardized mortality ratios (SMRs; U.S., state, and county referents) and Poisson regression modeling. RESULTS: Mortality from NHL, melanoma, and rectal, breast, and brain cancers were neither in excess nor associated with cumulative exposure. Mortality was not elevated for liver cancer [21 deaths; SMR 0.89; 95% confidence interval (CI), 0.55-1.36], but increased with cumulative exposure (trend p-value = 0.071). Among men, stomach cancer mortality was elevated (24 deaths; SMR 1.53; 95% CI, 0.98-2.28) and increased with cumulative exposure (trend p-value = 0.039). Among women, intestinal cancer mortality was elevated (67 deaths; SMR 1.31; 95% CI, 1.02-1.66), especially in higher cumulative exposure categories, but without a clear trend. Prostate cancer mortality, which was not elevated (34 deaths; SMR 1.04; 95% CI, 0.72-1.45), increased with cumulative exposure (trend p-value = 0.0001). CONCLUSIONS: This study corroborates previous studies showing increased liver cancer mortality, but we cannot clearly associate rectal, stomach, and intestinal cancers with PCB exposure. This is the first PCB cohort showing a strong exposure-response relationship for prostate cancer mortality. |
| Doi | 10.1289/ehp.9175 |
| Pmid | 17035134 |
| Wosid | WOS:000240969700025 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Adult; Cause of Death; Cohort Studies; *Electricity; Female; Humans; Male; Neoplasms/*chemically induced/classification/*mortality; *Occupational Exposure; Polychlorinated Biphenyls/*toxicity; 0 (Polychlorinated Biphenyls) |
| Is Qa | No |