Antiamebic activity of marine sponge Haliclona exigua (Krikpatrick)
Lakshmi, V; Saxena, A; Mishra, SK; Mishra, M; Srivastava, S; Ghoshal, S
HERO ID
1131067
Reference Type
Journal Article
Year
2009
Language
English
| HERO ID | 1131067 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Antiamebic activity of marine sponge Haliclona exigua (Krikpatrick) |
| Authors | Lakshmi, V; Saxena, A; Mishra, SK; Mishra, M; Srivastava, S; Ghoshal, S |
| Journal | Bangladesh Journal of Pharmacology |
| Volume | 4 |
| Issue | 1 |
| Page Numbers | 55-59 |
| Abstract | The methanol and methanol-chloroform (1:1) extracts of the freshly collected Haliclona exigua showed minumim inhibitory concentration (MIC) of 125 mu g/ml and 250 mu g/ml respectively in in vitro studies, but when both of these were tested in vivo in rats, only methanol-chloroform showed 80% inhibition of trophozoites at the dose of 900 mg/kg body weight against Entameba histolytica. Therefore only methanol-chloroform extract was further fractionated into four fractions (n-hexane, chloroform, n-butanol soluble and n-butanol insoluble fractions). Out of these, only n-hexane and n-butanol soluble fractions showed 80% inhibition of trophozoites at 900 mg/kg dose. Further the chromatography of the n-butanol fraction yielded araguspongin-C which showed promising results at different doses. |
| Doi | 10.3329/bjp.v4i1.1083 |
| Wosid | WOS:000270091100013 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000270091100013Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-68049096195&doi=10.3329%2fbjp.v4i1.1083&partnerID=40&md5=d9f73bd05c8fcb09a819b0fdc9c57570 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Alkaloid; Anti-amebic activity; Araguspongin-C; Haliclona exigua; Marine sponge |
| Is Qa | No |