Cholinesterase and lipoxygenase inhibition of whole plant Withania somnifera
Khan, H; Tariq, SA; Khan, MA; Inayat-Ur-Rehman; Ghaffar, R; Saifullah
| HERO ID | 1108243 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Cholinesterase and lipoxygenase inhibition of whole plant Withania somnifera |
| Authors | Khan, H; Tariq, SA; Khan, MA; Inayat-Ur-Rehman; Ghaffar, R; Saifullah |
| Journal | African Journal of Pharmacy and Pharmacology |
| Volume | 5 |
| Issue | 20 |
| Page Numbers | 2272-2275 |
| Abstract | To discover new therapeutically effective and safe cholinesterase and lipoxygenase inhibitors, crude methanol extract and subsequent solvent fractions of Withania somnifera Dunal were screened for their inhibitory profile. Results revealed marked overall inhibition. Against acetylcholinesterase, the IC(50) values were in the range of 69 to 111 mu g/ml, except hexane fraction. Similarly, profound lipoxygenase attenuation was observed (IC(50): 76 to 132 mu g/ml) for extracts with the exception of hexane fraction. It is notable that among the extracts, chloroform fraction was the most dominant inhibitor of the tested enzymes. This study indeed provides a strong scientific rationale for the folk use of the plant for the loss of memory and as anti-inflammatory. |
| Doi | 10.5897/AJPP11.575 |
| Wosid | WOS:000299675800013 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000299675800013 Journal:AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGYScopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-82755187195&doi=10.5897%2fAJPP11.57&partnerID=40&md5=69c7e79bfe8af70f188f2274aac1b980 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Withania somnifera; Solanaceae; cholinesterase and lipoxygenase inhibition |
| Is Qa | No |