Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: Results with 46 chemicals
Loveday, KS; Anderson, BE; Resnick, MA; Zeiger, E; Holden, HE
HERO ID
106324
Reference Type
Journal Article
Year
1990
Language
English
PMID
| HERO ID | 106324 |
|---|---|
| In Press | No |
| Year | 1990 |
| Title | Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: Results with 46 chemicals |
| Authors | Loveday, KS; Anderson, BE; Resnick, MA; Zeiger, E; Holden, HE |
| Journal | Environmental and Molecular Mutagenesis |
| Volume | 16 |
| Issue | 4 |
| Page Numbers | 272-303 |
| Abstract | Forty-six coded chemicals were tested for their ability to induce sister chromatid exchanges (SCEs) and chromosomal aberrations (ABs) in cultured Chinese hamster ovary (CHO) cells using a standard protocol with and without exogenous metabolic activation. Sixteen chemicals were negative and 15 were positive in both assays; 15 were positive for SCEs only (one chemical that was positive for SCEs was equivocal for ABs), and no chemicals induced ABs only. The effect of cell harvest time on the ability to detect the induction of ABs was examined for 18 chemicals. Seven chemicals produced a positive response using both standard and extended harvest times, five were positive only using an extended harvest time, and six were negative using both harvest times. The relationship between cell cycle delay and SCE induction was also examined, and the two appear to be unrelated. |
| Doi | 10.1002/em.2850160409 |
| Pmid | 2253606 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: ENVIRON MOL MUTAGEN 16 ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | mammalian cells; CHO cells; cell cycle delay |
| Relationship(s) |
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