Number of solution states of bradykinin from ion mobility and mass spectrometry measurements
Pierson, NA; Chen, L; Valentine, SJ; Russell, DH; Clemmer, DE
HERO ID
1048233
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 1048233 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Number of solution states of bradykinin from ion mobility and mass spectrometry measurements |
| Authors | Pierson, NA; Chen, L; Valentine, SJ; Russell, DH; Clemmer, DE |
| Journal | Journal of the American Chemical Society |
| Volume | 133 |
| Issue | 35 |
| Page Numbers | 13810-13813 |
| Abstract | Ion mobility and mass spectrometry measurements have been used to examine the populations of different solution structures of the nonapeptide bradykinin. Over the range of solution compositions studied, from 0:100 to 100:0 methanol:water and 0:100 to 90:10 dioxane:water, evidence for 10 independent populations of bradykinin structures in solution is found. In some solutions as many as eight structures may coexist. The solution populations are substantially different than the gas-phase equilibrium distribution of ions, which exhibits only three distinct states. Such a large number of coexisting structures explains the inability of traditional methods of characterization such as nuclear magnetic resonance spectroscopy and crystallography to determine detailed structural features for some regions of this peptide. |
| Doi | 10.1021/ja203895j |
| Pmid | 21830821 |
| Wosid | WOS:000295241400012 |
| Url | https://pubs.acs.org/doi/10.1021/ja203895j |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000295241400012 |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |