Assessment of dermal absorption by thermogravimetric analysis: Development of a diffusion model based on Fick's second law
Rauma, M; Johanson, G
| HERO ID | 1041244 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Assessment of dermal absorption by thermogravimetric analysis: Development of a diffusion model based on Fick's second law |
| Authors | Rauma, M; Johanson, G |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 98 |
| Issue | 11 |
| Page Numbers | 4365-4375 |
| Abstract | Recent work in our laboratory shows that it is possible to reproducibly measure the weight change over time of a piece of porcine skin exposed to a chemical vapor by thermogravimetric analysis (TGA), that is, using a microbalance maintained at constant temperature and humidity. Here, we develop a diffusion model by which the TGA skin weight curve can be interpreted. A TGA-specific analytical solution for Fick's second law of diffusion was derived. The solution contains two chemical-dependent parameters; a diffusion coefficient (D) and a skin/air partition coefficient (P). The resulting function was fitted to weight curves from 83 experiments with 4 chemicals; n-butyl acetate, methanol, 2-propanol, and toluene. In most experiments, a single weight function could not adequately describe the shape of the weight curve, therefore up to five parallel compartments, each with its parameter set Di and Pi, were tested. A two-compartment model was adequate for 58% of the experiments according to the Akaike Information Criterion. Dermal penetration of the chemicals was also measured with Franz diffusion cells. The diffusion coefficients obtained by the two methods agreed well. |
| Doi | 10.1002/jps.21709 |
| Pmid | 19283759 |
| Wosid | WOS:000271595800037 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science 000271595800037 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Static diffusion cell; pig; n-butyl acetate; methanol; 2-propanol; toluene; Akaike Information Criterion; TGA; diffusion; dermal absorption; thermal gravimetric analysis |
| Is Qa | No |