Failure of chloroform to induce chromosome damage or sister-chromatid exchanges in cultured human lymphocytes and failure to induce reversion in Escherichia coli
Kirkland, DJ; Smith, KL; Van Abbe, NJ
| HERO ID | 10058 |
|---|---|
| In Press | No |
| Year | 1981 |
| Title | Failure of chloroform to induce chromosome damage or sister-chromatid exchanges in cultured human lymphocytes and failure to induce reversion in Escherichia coli |
| Authors | Kirkland, DJ; Smith, KL; Van Abbe, NJ |
| Journal | Food and Cosmetics Toxicology |
| Volume | 19 |
| Issue | 5 |
| Page Numbers | 651-656 |
| Abstract | Two strains of Escherichia coli, WP2p and WP2uvrA−p, were treated with chloroform in the plate incorporation assay, and in liquid pre-incubation tests, and in both cases the chemical did not induce reversions. Chloroform, with metabolic activation (addition of S-9 mix), also failed to induce chromosome breakage or sister-chromatid exchanges in human lymphocytes, but benzo[a]pyrene, with and without S-9 mix, induced significant chromosome breakage and sister-chromatid exchanges in lymphocytes from the same donor. The relevance of these results in the light of other negative in vitro tests on chloroform, and positive and negative carcinogenicity tests, is discussed. |
| Doi | 10.1016/0015-6264(81)90517-4 |
| Pmid | 6273272 |
| Wosid | WOS:A1981MR25100017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Escherichia coli is italicized. Food Cosmet. Toxicol. 19: 651-656. |
| Is Public | Yes |
| Language Text | English |
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