Abstract  The 96 h EL values could not be accurately determined due to large variations in cell concentrations. The EC50 values determined are reliant on confounding factors due to the concentrations used (exceedinly higher than the limit of solubility) and therefore should be treated with caution. The water solubility of octadecanol is 0.0011 mg/L at 25oC [SIDS dossier on 1-octadecanol, 1993b; Budavari, 1996]. The results indicate that no toxic effects were present at the limit of solubility of the test substance, i.e. EL50 and NOEC >0.0011 mg/L (>LoS).

Abstract  Effectiveness of certain long carbon chain aliphatic alcohols as ovicides and larvicides was investigated under laboratory conditions against eggs and larvae of Aedes aegypti and Aedes scutellaris. Out of the eight alcohols tested, three (1-decanol, 1-undecanol and 1-dodecanol) proved to be very effective. The hatching of mosquito eggs was inhibited at a dosage of 5 to 7 litres/hectare. First, third and fourth instar larvae were killed at a dosage of 3 to 7 litres/hectare. First instar larvae were more sensitive to the alcohols than the older larvae. The shorter carbon chain alcohols (2-mercapto-ethanol, 1-butanol, benzyl alcohol and 2-octanol) proved unsatisfactory due to their volatility and solubility. Longer carbon chain alcohols (1-tetradecanol, 1-hexadecanol and 1-octadecanol), Which are solid and wax-like at room temperature, proved unsatisfactory when dissolved in hexane and applied to eggs and larvae.

Abstract  A 96 h LC50 value of >0.4 mg/L was determined for the effect of the test substance on mortality of the fish O. mykiss. The water solubility of octadecanol is 0.0011 mg/L at 25oC [SIDS dossier on 1-octadecanol, 1993b; Budavari, 1996], therefore the LC50 value is >0.0011 mg/L, The water solubility of octadecanol is 0.0011 mg/L at 25oC [SIDS dossier on 1-octadecanol, 1993b; Budavari, 1996], therefore the LC50 value is >0.0011 mg/L (>LoS), i.e. the test substance was not toxic at the LoS.

Abstract  SIDS INITIAL ASSESSMENT: There is need for further work. SHORT SUMMARY OF THE REASONS WHICH SUPPORT THE RECOMMENDATION: The substance is firmly bound to sediments, and therefore anaerobic biodegradation can be an important factor. A 21-day test in daphnids indicated that the substance may be toxic at a range of between 1 and 3mg/l. FURTHER WORK RECOMMENDED: Determination of anaerobic biodegradability. Depending on the results of this test, it may be considered whether or not long-term fish toxicity testing is required.

Abstract  SIDS dossiers already existed for 1-Dodecanol (CAS 112-53-8) and 1-Octadecanol (CAS 112-92-5) (published in 1998 and 1995 respectively); the present document updates and extends the earlier ones; brings in new information, and therefore replaces it. No conclusions drawn in the earlier review are amended. Available data for these substances are compiled in SIDS dossiers related to each CAS number. The reliability of each data point has been considered during this period of review, in accordance with the guidance of the Fraunhofer Institut für Toxikologie und Aerosolforschung. The following standard reliability codes, defined by Klimisch et al. (1997)1, apply, in accordance with the SIDS guidance: (1) Valid without restriction (2) Valid with restrictions (3) Invalid (4) Not assignable. Results considered to be Invalid are not used in the discussions or conclusions in this report. However, results which are of Non-assignable reliability may be fully valid, although insufficient details were available to be sure of this; therefore reliability (4) results are used in this report. The reliability code of each data point is given. Key studies are flagged in the SIDS dossiers. These are studies with the highest reliability/adequacy. If several studies showed comparable reliability/ adequacy, the study with the lowest LC/LD/EC50 or NOEC/ NOAEL has been indicated as the key study. For some endpoints, fully reliable results are not available and it has been necessary to use a weight of evidence including results of studies of non-assignable reliability. In such cases the results are identified as key studies as they are of high importance to the data set. For transparency, some study summaries in the SIDS dossier have been transferred from the previously published version of IUCLID or from the previous SIDS submission. In some cases, it has not been possible to retrieve the original literature/study reports using the reported citation or as a result of literature searching. In some cases, change of business ownership meant that internal study reports cited in previous summaries could not be accessed. In some other cases, e.g. certain non-SIDS endpoints, and in areas where a very large amount of literature has been published, it was not considered necessary to pursue all individual published sources due to weight of evidence of more reliable results. In all cases, reliability (4) applies, because the original documentation has not been reviewed in the development of the dossier. Such results are clearly identified in the SIDS dossier and more details are given therein.

Abstract  A 96 h LC50 value of >1000 mg/L tested with Water Accomodated Fractions (WAFs) has been calculated for the effects of docosan-1 -ol on Oncorhynchus mykiss. This result signifies that the test substance is not expected to be toxic at the limit of solubility. Due to the very low water solubility of the substance, the test was conducted with WAFs.The WAFs used in this study were filtered. This is the only experimental value available for this endpoint and therefore has been selected as key.

Abstract  A 48h EC50 value of 1700 mg/L has been determined for the effects of octadecanol on the mobility of Daphnia magna. The EC50 was obtained at a concentration above the Limit of Solubility (LoS) and should be treated with caution. The water solubility of octadecanol is 0.0011 mg/L at 25oC [SIDS dossier on 1-octadecanol, 1993b; Budavari, 1996], therefore the LC50 value is >0.0011 mg/L (>LoS), i.e. the test substance was not toxic at the LoS.