3-Methoxybutyl acetate

Project ID

2732

Category

OPPT

Added on

Sept. 11, 2018, 5:36 a.m.

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PubMed
DOI
Journal Article

Reproduction and teratology study of 1,3-butanediol in rats

Hess FG Jr et al. 1981

Abstract  The effect of 1,3-butanediol on reproductive performance as well as its teratogenic, dominant lethal and cytogenetic effects were studied in five generations of Wistar rats. Animals of both sexes were fed either control diet or diet supplemented with 1,3-butanediol at dose levels of 5, 10 or 24% of the diet by weight. Reproduction and lactation parameters were comparative to controls for four of five generations of dams and pups. In contrast, the pregnancy rate of F1A rats decreased during five successive mating cycles; no pups were obtained in the high-dose level group of the fifth series of litters (F2E generation). Excluding this group, the viability of F2 generation pups revealed no significant differences between litters or between control and test groups. No definitive dose-related teratological findings were found in either soft or skeletal tissue examinations of F3B generation rats. However, incomplete ossification of sternebrae occurred frequently in mid- and high-dose fetuses, whereas missing sternebrae were noted especially in high-level fetuses. Both skeletal tissue findings suggest slight delayed fetal growth. For the dominant lethal assay of the F1B generation, the mutagenic index (percentage resorptions per implant sites) revealed no dose-related trend. In the three-generation cytogenetic study, no 1,3-butanediol related chromosomal aberrations were noted.

Technical Report

3-Methoxybutyl acetate: Sensitisation data (human)

European Chemicals Agency 1973

Abstract  Under completely occluded conditions, Celanese Chemical Company - 50-50 Blend in Water of 1,3 Butylene Glycol, was capable of eliciting visible skin changes consistent with the criteria deemed characteristic of a mild fatiguing agent in 2 out of 200 subjects. In the opinion of the investigator, Celanese Chemical Company - 50-50 Blend in Water of 1, 3 Butylene Glycol may be considered safe to use in contact with the skin insofar as primary irritation or sensitization are concerned if the conditions of contact do not exceed those of the test procedure. Insofar as sensitization is concerned, the extrapolation of these results to a general population is limited statistically by the number of test subjects. In this case, since 200 subjects were used, we may predict with 95% certainty that at least 98.17% of a general population will not be sensitized by this material.

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