OPPT_N-methylpyrrolidone (NMP)_F. Human Health

Project ID

2586

Category

OPPT REs

Added on

March 8, 2017, 8:52 a.m.

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Technical Report

TSCA work plan chemical risk assessment. N-Methylpyrrolidone: Paint stripper use (CASRN: 872-50-4)

U.S. Environmental Protection Agency 2015

Abstract  As a part of EPA’s comprehensive approach to enhance the Agency’s existing chemicals management program, in March 2012 EPA identified a work plan of chemicals for further assessment under the Toxic Substances Control Act (TSCA)1. The Agency is performing risk assessments on chemicals in this work plan. If an assessment identifies unacceptable risks to humans or the environment, EPA will pursue risk reduction. EPA/OPPT assessed Nmethylpyrrolidone, also referred to as 1-methyl-2-pyrrolidinone (TSCA inventory name) or NMP, as part of this work plan. NMP is a solvent that exhibits low volatility, low flammability and no explosivity. It has low persistence and low bioaccumulation potential in the environment. NMP is produced or imported to the US in large quantities (i.e., 184.7 million lbs in 2012). It has a variety of TSCA uses including: petrochemical processing, engineering plastics, coatings (i.e., resins, paints, finishes, inks and enamels), paint stripping, agricultural chemicals, electronic cleaning and industrial/domestic cleaning. In the work plan, EPA/OPPT identified NMP for further evaluation based on high concern for hazard due to its reproductive toxicity and high concern for potential exposure due to use in consumer products. During scoping and problem formulation, EPA/OPPT considered all TSCA uses and chose to focus on occupational and consumer paint stripping uses because of high content in products and high potential exposure to workers and consumers. In addition, EPA/OPPT reviewed available toxicological data and existing risk assessments and concluded that the data on developmental toxicity was more relevant, consistent and sensitive than the reproductive toxicity data. Therefore the NMP hazard identification focused on developmental toxicity.

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