OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_B. Ecological Toxicology

Project ID

2557

Category

OPPT REs

Added on

March 8, 2017, 8:12 a.m.

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Technical Report

Abstract  Product information sheet, MSDS, and Toxicity Data Summaries: acute oral rats, acute dermal rabbits, primary skin irritation rabbits, eye irritation rabbits, acute inhalation rats, Ames test, acute fish toxicity test, pilot cataractogenic study in chicks, cataractogenic study in chicks, biodegradation, hydrolysis, partition coefficient, solubility,

Technical Report

Abstract  Notice of initiation of 28-day repeated dose oral toxicity study of HBCD in rats

Technical Report

Abstract  Notice of initiation of 7 studies on HBCD: acute fish test, acute daphnid test, algal toxicity test, analytical method verification for the determination of HBCD in well water, determination of water solubility, determination of n-octanol/water partition coefficient, evaluation of hydrolysis as a function of pH

Technical Report
Technical Report

Abstract  Notice of initiation of a maximization test in guinea pigs and chromosomal aberrations in human peripheral blood

Technical Report

Abstract  Final report of a 90-day oral gavage toxicity study in rats (converted from 8EHQ-0102-15040A) / A 90-Day Oral (Gavage) Toxicity Study of HBCD in Rats

Technical Report

Abstract  An industrial hygiene survey was conducted at the El Dorado plant to determine employee exposure to phenol, tribromophenol (TBP), ethylene dibromide (EDB) and epichlorohydrin in the fire-Master 680 (FM-680) unit and employee exposures to bromoacetaldehyde dimethyl acetal (BADMA), dibromoethyl acetate (DBEA), hexabromocyclododecane (HBCD), ethylene dichloride (EDC), methyl bromide and ethanol in the Semi-Works operations. The survey was performed by Neal Netzel, Industrial Hygienist, Environmental Health and Hygiene Department, during the week of March 6, 1978. The analytical support was furnished by both the Velsicol Ann Arbor Research facility and Clayton Environmental Consultants, Inc. Final lab results were received on April 17, 1978.

Technical Report

Abstract  Hexabromocyclododecane was evaluated for mutagenicity by plate assay in the bacterium, Salmonella typhimurium, strains TA1535, TA1537, TA98, and TA100, both in the presence and absence of Aroclor 1254-induced rat liver homogenate. Positive (substance not identified), solvent (acetone), and untreated controls were utilized. Test concentrations ranged from 0.05 to 5.0 mg/plate. The high dose did not produce toxicity in any strain. A dose-related increase was observed in the number of revertant colonies in strains TA100 and TA1535 both in the presence and absence of metabolic activation.

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