OPPT_1-Bromopropane (1-BP)_C. Engineering

Project ID

2549

Category

OPPT REs

Added on

March 7, 2017, 3:34 p.m.

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Technical Report

Scientific review of 1-bromopropane occupational exposure limit derivations – preliminary thoughts and areas for further analysis

Toxicology Excellence for Risk Assessment 2004

Abstract  Current OELs for 1-bromopropane (1-BP) are diverse in both the selection of critical effects and judgments of remaining uncertainties. The resulting values differ by ~16-fold. We critically evaluated the underlying basis of existing OELs through the use of concepts such as critical effect, benchmark dose and uncertainty factor. We conclude that the critical effect is decreased live litter size with a BMDL of 190 ppm. Using an uncertainty factor of 10-fold, 3 for extrapolation from an animal study and 3 for human variability results in an OEL of 20 ppm.

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