OPPT_1-Bromopropane (1-BP)_F. Human Health

Project ID

2547

Category

OPPT REs

Added on

March 7, 2017, 3:31 p.m.

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27 items found. Displaying 25 items on page 1 of 2.

Technical Report

Scientific review of 1-bromopropane occupational exposure limit derivations – preliminary thoughts and areas for further analysis

Toxicology Excellence for Risk Assessment 2004

Abstract  Current OELs for 1-bromopropane (1-BP) are diverse in both the selection of critical effects and judgments of remaining uncertainties. The resulting values differ by ~16-fold. We critically evaluated the underlying basis of existing OELs through the use of concepts such as critical effect, benchmark dose and uncertainty factor. We conclude that the critical effect is decreased live litter size with a BMDL of 190 ppm. Using an uncertainty factor of 10-fold, 3 for extrapolation from an animal study and 3 for human variability results in an OEL of 20 ppm.

Technical Report

NIOSH Health Hazard Evaluation Report: HETA No. 98-0153-2883, Custom Products, Inc. Mooresville, NC

Reh CM et al. 2002

Abstract  The Hazard Evaluations and Technical Assistance Branch (HETAB) of the National Institute for Occupational Safety and Health (NIOSH) conducts field investigations of possible health hazards in the workplace. These investigations are conducted under the authority of Section 20(a)(6) of the Occupational Safety and Health (OSHA) Act of 1970, 29 U.S.C. 669(a)(6) which authorizes the Secretary of Health and Human Services, following a written request from any employer or authorized representative of employees, to determine whether any substance normally found in the place of employment has potentially toxic effects in such concentrations as used or found. This Health Hazard Evaluation was requested by the North Carolina Department of Labor to address concerns about possible health problems related to working with a spray adhesive (that contains the chemical 1- bromopropane (1-BP)).

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